Case: How Fondaparinux (Arixtra) is different in Mechanism of action from heparins (unfractionated and low molecular weights), which may give it advantage of not causing HIT (Heparin induced Thrombocytopenia)?
Answer : Fondaparinux (ARIXTRA) is the synthetic Factor Xa inhibitor. While other antithrombotics may inhibit multiple factors in the coagulation cascade, Fondaparinux selectively inhibits only Factor Xa. Fondaparinux is not a heparin. Fondaparinux is the pentasaccharide antithrombotic agent inhibiting only factor Xa.
